Liquid Nitrogen is applied to the skin either with a cotton applicator or via a pressurised spray to freeze the surface layers.

Cryosurgery can be used to treat benign surface lesions, sun damage and is occasionally used for the treatment of some forms of skin cancer. After treatment there is a local inflammatory reaction. With a short freeze there is some discomfort then the site swells slightly and feels like a burn before settling after a few hours and the surface layers then peel over a few days. An intense treatment is painful and may require local anaesthesia. A blister will form which may require regular dressings whilst it heals over 10-14 days.